viernes, 9 de enero de 2015

Electronic dura mater for long-term multimodal neural interfaces

Electronic dura mater for long-term multimodal neural interfaces





Science
Vol. 347 no. 6218 pp. 159-163 
DOI: 10.1126/science.1260318
  • REPORT

Electronic dura mater for long-term multimodal neural interfaces

  1. Stéphanie P. Lacour1,,
+Author Affiliations
  1. 1Bertarelli Foundation Chair in Neuroprosthetic Technology, Laboratory for Soft Bioelectronic Interfaces, Centre for Neuroprosthetics, Institute of Microengineering and Institute of Bioengineering, Ecole Polytechnique Fédérale de Lausanne (EPFL), Switzerland.
  2. 2International Paraplegic Foundation Chair in Spinal Cord Repair, Centre for Neuroprosthetics and Brain Mind Institute, EPFL, Switzerland.
  3. 3Pavlov Institute of Physiology, St. Petersburg, Russia.
  4. 4Translational Neural Engineering Laboratory, Center for Neuroprosthetics and Institute of Bioengineering, EPFL, Lausanne, Switzerland.
  5. 5School of Engineering and Applied Sciences, Kavli Institute for Bionano Science and Technology, Harvard University, Cambridge, MA, USA.
  6. 6Laboratory for Biosensors and Bioelectronics, Institute for Biomedical Engineering, University and ETH Zurich, Switzerland.
  7. 7The BioRobotics Institute, Scuola Superiore Sant’Anna, Pisa 56025, Italy.
  1. Corresponding author. E-mail: gregoire.courtine@epfl.ch (G.C.); stephanie.lacour@epfl.ch (S.P.L.)
  1. * These authors contributed equally to this work.
  2.  These authors contributed equally to this work.
The mechanical mismatch between soft neural tissues and stiff neural implants hinders the long-term performance of implantable neuroprostheses. Here, we designed and fabricated soft neural implants with the shape and elasticity of dura mater, the protective membrane of the brain and spinal cord. The electronic dura mater, which we call e-dura, embeds interconnects, electrodes, and chemotrodes that sustain millions of mechanical stretch cycles, electrical stimulation pulses, and chemical injections. These integrated modalities enable multiple neuroprosthetic applications. The soft implants extracted cortical states in freely behaving animals for brain-machine interface and delivered electrochemical spinal neuromodulation that restored locomotion after paralyzing spinal cord injury.
  • Received for publication 22 August 2014.
  • Accepted for publication 27 November 2014.


No hay comentarios:

Publicar un comentario