Genomics|Update|Current ▲ Cancer

Genomics|Update|Current

Cancer

NCI-sponsored trials in precision medicine, October 2014

Gene expression profiling in women with lymph node‒negative breast cancer to select adjuvant chemotherapy,  [PDF 1.99 MB] TEC Assessment BlueCross BlueShield Association, Oct 2014

Attitudes regarding privacy of genomic information in personalized cancer therapy 
Rogith D, et al. J Am Med Inform Assoc 2014 Oct;21(e2):e320-5

Biomarker analyses in CLEOPATRA: A phase III, placebo-controlled study of pertuzumab in human epidermal growth factor receptor 2–positive, first-line metastatic breast cancer. 
José Baselga et al. Journal Clinical Oncology, October 20, 2014

Cancer information seeking in the digital age: Effects of Angelina Jolie's prophylactic mastectomy announcement 
Noar SM, et al. Med Decis Making 2014 Oct

Celebrity disclosures and information seeking: the case of Angelina Jolie 
Juthe RH, et al. Genet Med 2014 Oct

Genetic and environmental risk assessment and colorectal cancer screening in an average-risk population: a randomized trial.
Weinberg DS, et al. Ann Intern Med. 2014 Oct 21;161(8):537-45.

Knowing cancer risk may not affect screening rates, by Nicholas Bakalar, New York Times, Oct 29

Knowing genetic risk for cancer may not change behavior, by Randy Dotinga, Health Day, Oct 24

Is it all Lynch syndrome?: An assessment of family history in individuals with mismatch repair–deficient tumors. 
Katherine M. Dempsey et al. Genetics in Medicine, October 23, 2014  

Limited family structure and triple-negative breast cancer (TNBC) subtype as predictors of BRCA mutations in a genetic counseling cohort of early-onset sporadic breast cancers 
Zugazagoitia J, et al. Breast Cancer Res Treat 2014 Oct

Long-term psychosocial and behavioral adjustment in individuals receiving genetic test results in Lynch syndrome.
Esplen M, et al. Clin Genet. 2014 Oct 9.

Obtaining informed consent for clinical tumor and germline exome sequencing of newly diagnosed childhood cancer patients.
Scollon S. et al.  Genome Med. 2014 Sep 17;6(9):69.

The impact of risk-reducing gynaecological surgery in premenopausal women at high risk of endometrial and ovarian cancer due to Lynch syndrome 
Moldovan R, et al. Fam Cancer 2014 Oct

The role of genome sequencing in personalized breast cancer prevention.
Sieh W, et al. Cancer Epidemiol Biomarkers Prev. 2014 Oct 23.

Here’s how well your genes can predict your breast cancer risk, by Alice Park, Time, Oct 23

Toward a system plan for transforming cancer care to a molecular-based approach: Recommendations from an expert panel. 
Anthony Flynn, et al. Applied and Translational Genomics, October 2014 

Use of risk-reducing surgeries in a prospective cohort of 1,499 BRCA1 and BRCA2 mutation carriers.
Chai X, et al. Breast Cancer Res Treat. 2014 Oct 14.

Cancer cells can ‘infect’ normal neighbours. Tiny RNAs shed by tumours can transform healthy cells into cancerous ones, by Heidi Ledford, Nature News, Oct 23

JCO Exclusive: Predicting response to anti-HER2 treatments: Is HER2 the only biomarker? ASCO Connection, Oct 27