CancerGEM KB|Home ▲ CancerGEM KB (Cancer Genomic Evidence-based Medicine Knowledge Base) (version 1.0)

CancerGEM KB|Home

  CancerGEM KB (Cancer Genomic Evidence-based Medicine Knowledge Base) (version 1.0)
   An integrated, searchable knowledge base of cancer human genome epidemiology and genomic applications in cancer care and prevention . 

Office of Public Health Genomics/CDC launches the CancerGEM KB : CDC Office of Public Health Genomics in collaboration with NCI Division of Cancer Control and Population Sciences launches the CancerGEM KB: CancerGEM KB is an online resource for researchers, public health professionals, policy makers, and health care providers interested in the use of genomic information in cancer care and prevention. CancerGEM KB provides objective synthesis and timely dissemination of information on cancer human genome epidemiology (genetic associations, gene-environment interactions and gene prevalence information) and aggregated evidence on cancer genomic tests in transition to clinical and public health practice. CancerGEM KB also offers summary information on Genomic Tests through PLoS Currents Evidence on Genomic Tests, an open-access journal for systematic reviews and structured short summaries of evidence for the validity and utility of genetic tests. Read more about CancerGEM KB

News related to genomic applications in cancer care and prevention

• World News Report, May 29: Genetic susceptibility to breast cancer: a new, more accurate diagnostic test for mutation screening
• Medical Xpress, May 29: World's largest release of comprehensive human cancer genome data helps speed discoveries
• Medscape, May 22 [by free subscription only]: Genetic abnormalities increase risk for prostate cancer death
• Cleveland.com, May 21: Task force discourages use of prostate cancer screening test
• Science Codex, May 20: Scientists discover distinct molecular subtype of prostate cancer  

Potential Genomic Tests  recently added in Cancer Genomic Test Finder

• 05/31/2012 : Non-small cell lung cancer (NSCLC) - Real-time PCR assay, detection of 28 somatic mutations in EGFR gene; amplification refractory mutation system (ARMS) PCR technology, fluorescent probe detection . See detail
• 05/31/2012 : Multiple conditions - Genotyping more than 700,000 SNPs, chip-based method; saliva sample . See detail
• 05/31/2012 : Multiple conditions - Genotyping multiple variants using PCR/chip-based method; saliva sample . See detail
• 05/17/2012 : Ovarian cancer - Scoring system based on expression of 23 genes involved in platinum-induced DNA repair pathways . See detail
• 05/17/2012 : Cancer - Web-based program makes simulated pyrograms based on input such as: percentage of tumor vs normal cells, wild-type sequence, etc.; calculates relative mutant and wild-type allele percentages, generates expected signal at each point in dispensation sequence based on these data. . See detail

 Published Literature  recently added in Cancer HuGE Literature Finder

• A Pooled Exploratory Analysis of the Effect of Tumor Size and KRAS Mutations on Survival Benefit From Adjuvant Platinum-Based Chemotherapy in Node-Negative Non-Small Cell Lung Cancer.
  Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 2012 Jun 7 (6): 6.
  Cuffe S, Bourredjem A, Graziano S, Pignon JP, Domerg C, Ezzalfani M, Seymour L, Strevel E, Burkes R, Capelletti M, Jänne PA, Tsao MS, Shepherd FA
• Incidence of BRAF p.Val600Glu and p.Val600Lys mutations in a consecutive series of 183 metastatic melanoma patients from a high incidence region.
  Pathology 2012 Jun 44 (4): 4.
  Amanuel B, Grieu F, Kular J, Millward M, Iacopetta B
• Loss of PTEN expression as a predictor of resistance to anti-EGFR monoclonal therapy in metastatic colorectal cancer: evidence from retrospective studies.
  Cancer chemotherapy and pharmacology 2012 Jun 69 (6): 6.
  Wang ZH, Gao QY, Fang JY
• Prevalence of BRCA mutations in an unselected population of triple-negative breast cancer.
  Cancer 2012 Jun 118 (11): 11.
  Hartman AR, Kaldate RR, Sailer LM, Painter L, Grier CE, Endsley RR, Griffin M, Hamilton SA, Frye CA, Silberman MA, Wenstrup RJ, Sandbach JF
• Suggestive evidence of linkage identified at chromosomes 12q24 and 2p16 in African American prostate cancer families from louisiana.
  The Prostate 2012 Jun 72 (9): 9.
  Ledet EM, Sartor O, Rayford W, Bailey-Wilson JE, Mandal DM 

Published Evidence  recently added in Cancer Evidence Aggregator

• Garrett Dancik, Dara Aisner, Dan Theodorescu . A 20 gene model for predicting nodal involvement in bladder cancer patients with muscle invasive tumors . 07/21/2011. See detail
• Naoko Ishibe, Josh Carlson, Scott David. Ramsey, Andrew Freedman, Sheri Schully . Use of Epidermal Growth Factor Receptor Mutation Analysis in Patients with Advanced Non-Small-Cell Lung Cancer to Determine Erlotinib Use as First-Line Therapy . 07/11/2011. See detail
• Ralph Coates, Marc Williams, Stephanie Melillo . Genetic Testing for Lynch Syndrome in Individuals Newly Diagnosed with Colorectal Cancer to Reduce Morbidity and Mortality from Colorectal Cancer in Their Relatives . 07/07/2011. See detail
• Christine M. Nguyen, Margaret A. Mendes, Joseph D. Ma . Thiopurine methyltransferase (TPMT) genotyping to predict myelosuppression risk . 05/15/2011. See detail
• Renée M. Ned, Stephanie Melillo, Michael Marrone . Fecal DNA testing for Colorectal Cancer Screening: the ColoSure test . 03/08/2011. See detail