martes, 20 de marzo de 2012

Aromatase Inhibitors: Links to NCI Materials - National Cancer Institute

Aromatase Inhibitors: Links to NCI Materials - National Cancer Institute


Links to NCI Materials

Many breast tumors are "estrogen sensitive," meaning the hormone estrogen helps them to grow. Aromatase inhibitors (AIs) can help block the growth of these tumors by lowering the amount of estrogen in the body.
Estrogen is produced by the ovaries and other tissues of the body, using a substance called aromatase. AIs do not block estrogen production by the ovaries, but they can block other tissues from making this hormone. That's why AIs are used mostly in women who have reached menopause, when the ovaries are no longer producing estrogen.
Another drug, tamoxifen (Nolvadex®), also helps to prevent the growth of estrogen-sensitive breast tumors, but it works differently from AIs. Whereas AIs reduce the amount of estrogen in the body, tamoxifen blocks a tumor's ability to use estrogen.
Currently, three AIs are approved by the U.S. Food and Drug Administration: anastrazole (Arimidex®), exemestane (Aromasin®), and letrozole (Femara®).

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