A genome-wide association study in Europeans and S... [Nat Genet. 2011] - PubMed result

Nat Genet. 2011 Mar 6. [Epub ahead of print]

A genome-wide association study in Europeans and South Asians identifies five new loci for coronary artery disease.
The Coronary Artery Disease (C4D) Genetics Consortium; Steering and Writing committee, Peden JF, Hopewell JC, Saleheen D, Chambers JC, Hager J, Soranzo N, Collins R, Danesh J, Elliott P, Farrall M, Stirrups K, Zhang W, Hamsten A, Parish S, Lathrop M, Watkins H Chair, Clarke R, Deloukas P, Kooner JS; Statistical genetics and bioinformatics, Goel A, Ongen H, Strawbridge RJ, Heath S, Mälarstig A, Helgadottir A, Ohrvik J, Murtaza M, Potter S, Hunt SE; Genotyping, Delepine M, Jalilzadeh S, Axelsson T, Syvanen AC, Gwilliam R, Bumpstead S, Gray E, Edkins S; Expression QTL analyses, Folkersen L, Kyriakou T, Franco-Cereceda A, Gabrielsen A, Seedorf U; the MuTHER consortium, Eriksson P; Discovery cohorts, Offer A, Bowman L, Sleight P, Armitage J, Peto R, Abecasis G, Ahmed N, Caulfield M, Donnelly P, Froguel P, Kooner AS, McCarthy MI, Samani NJ, Scott J, Sehmi J, Silveira A, Hellénius ML, van 't Hooft FM, Olsson G, Rust S, Assmann G, Barlera S, Tognoni G, Franzosi MG, Linksted P, Green FR, Rasheed A, Zaidi M, Shah N, Samuel M, Mallick NH, Azhar M, Zaman KS, Samad A, Ishaq M, Gardezi AR, Memon FU, Frossard PM; Replication cohorts, Spector T, Peltonen L, Nieminen MS, Sinisalo J, Salomaa V, Ripatti S, Bennett D, Leander K, Gigante B, de Faire U, Pietri S, Gori F, Marchioli R, Sivapalaratnam S, Kastelein JJ, Trip MD, Theodoraki EV, Dedoussis GV, Engert JC, Yusuf S, Anand SS.

1] Department of Cardiovascular Medicine, The Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK. [2] Department of Cardiovascular Medicine, University of Oxford, John Radcliffe Hospital, Headington, Oxford, UK. [3].


Abstract
Genome-wide association studies have identified 11 common variants convincingly associated with coronary artery disease (CAD), a modest number considering the apparent heritability of CAD. All of these variants have been discovered in European populations. We report a meta-analysis of four large genome-wide association studies of CAD, with ∼575,000 genotyped SNPs in a discovery dataset comprising 15,420 individuals with CAD (cases) (8,424 Europeans and 6,996 South Asians) and 15,062 controls. There was little evidence for ancestry-specific associations, supporting the use of combined analyses. Replication in an independent sample of 21,408 cases and 19,185 controls identified five loci newly associated with CAD (P < 5 × 10(-8) in the combined discovery and replication analysis): LIPA on 10q23, PDGFD on 11q22, ADAMTS7-MORF4L1 on 15q25, a gene rich locus on 7q22 and KIAA1462 on 10p11. The CAD-associated SNP in the PDGFD locus showed tissue-specific cis expression quantitative trait locus effects. These findings implicate new pathways for CAD susceptibility.

PMID: 21378988 [PubMed - as supplied by publisher]

A genome-wide association study in Europeans and S... [Nat Genet. 2011] - PubMed result