Curr Opin Genet Dev. 2011 Jan 27. [Epub ahead of print]
Where are the missing pieces of the schizophrenia genetics puzzle?
Girard SL, Xiong L, Dion PA, Rouleau GA.
Centre of Excellence in Neuromics of Université de Montréal, CHUM Research Center, Montreal, Quebec, H2L 4M1, Canada.
Abstract
On the basis of recent data from candidate region/gene and genome-wide association studies (GWAS) and their follow-up investigations, the number of genes potentially implicated in schizophrenia has been estimated to be over 1000. However, with regard to the identified odds ratio, it is likely that genetic variants with more definitive effect on schizophrenia phenotype are still missing. The hunt therefore remains open for the genetic variants that would explain the majority of the missing heritability of schizophrenia. This review aims at summarizing data from recent DNA microarray and target gene/region resequencing in order to propose new insights of where to look next. The review is divided into three sections: GWAS, copy-number variations and rare variant-candidate gene resequencing.
Copyright © 2011. Published by Elsevier Ltd.
PMID: 21277191 [PubMed - as supplied by publisher]
Where are the missing pieces of the schizophrenia ... [Curr Opin Genet Dev. 2011] - PubMed result
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