Dorothy Hodgkin Lecture 2010^. From hype to hope? ... [Diabet Med. 2011] - PubMed result

Diabet Med. 2011 Feb;28(2):132-40. doi: 10.1111/j.1464-5491.2010.03194.x.
Dorothy Hodgkin Lecture 2010^. From hype to hope? A journey through the genetics of Type 2 diabetes.

McCarthy MI.

Oxford Centre for Diabetes, Endocrinology and MetabolismWellcome Trust Centre for Human Genetics, University of OxfordOxford NIHR Biomedical Research Centre, Churchill Hospital, Oxford, UK.

Abstract

Diabet. Med. 28, 132-140 (2011) ABSTRACT: Recent advances in genetic analysis have enabled researchers to perform genome-wide surveys for common DNA sequence variants associated with risk of Type 2 diabetes and related traits. Over the past 4 years, these endeavours have extended the number of proven Type 2 diabetes-susceptibility loci from a handful to the current total of over 40. Each of these loci provides an opportunity to uncover insights into the biology of glucose regulation and the pathogenesis of Type 2 diabetes, insights which should support clinical translation to identify novel ways of treating and preventing disease. Here, I describe (i) progress in identification of diabetes-susceptibility loci; (ii) biological insights that have been gained in the relatively short period since these loci were discovered; and (iii) the challenges that need to be addressed if we are to maximize the translational benefits of this research.
© 2011 The Author. Diabetic Medicine © 2011 Diabetes UK.

PMID: 21219419 [PubMed - in process]
Dorothy Hodgkin Lecture 2010^. From hype to hope? ... [Diabet Med. 2011] - PubMed result