Current Progress in Pharmacogenetics. [Br J Clin Pharmacol. 2011] - PubMed result

Br J Clin Pharmacol. 2011 Jan 14. doi: 10.1111/j.1365-2125.2011.03912.x. [Epub ahead of print]
Current Progress in Pharmacogenetics.

Blakey JD, Hall IP.

NIHR Clinical Lecturer Respiratory Biomedical Research Unit Clinical Sciences Building City Hospital Campus Nottingham NG5 1PB john.blakey@nottingham.ac.uk Dean and Professor of Molecular Medicine Division of Therapeutics and Molecular Medicine South Block Queen's Medical Centre Nottingham NG7 2UH ian.hall@nottingham.ac.uk.

Abstract

The study of genetic variation has the potential to aid understanding of the mechanisms underlying the observed inter-individual variation in drug response and by which idiosyncratic adverse effects occur. In this review, we outline current progress in pharmacogenetics using examples to highlight both mechanisms of influence of polymorphisms and research strategies for their detection. In the final sections we discuss contemporary challenges for both researchers and clinicians.
© 2011 The Authors. British Journal of Clinical Pharmacology © 2011 The British Pharmacological Society.

PMID: 21235621 [PubMed - as supplied by publisher]
Current Progress in Pharmacogenetics. [Br J Clin Pharmacol. 2011] - PubMed result