Study Published In 'Nature Genetics' Identifies Key Gene Linked To Blood Disorders

Study Published In 'Nature Genetics' Identifies Key Gene Linked To Blood Disorders
Main Category: Blood / Hematology
Also Included In: Genetics
Article Date: 06 Jul 2010 - 3:00 PDT

Researchers from the University of Southampton working in Salisbury have identified a key gene, which, if mutated, can cause serious blood disorders. The findings shed light on how these disorders develop and could lead to the design of new drugs for patients in the future that specifically target the genetic abnormality.

Using new genome scanning technology, the scientists examined the DNA of individuals with two groups of blood disorders - myeloproliferative neoplasms (MPN) and myelodysplastic syndromes (MDS). These disorders originate in the bone marrow and are usually characterised by the overproduction or underproduction, respectively, of red and white blood cells. Both disorders can be subdivided into several subtypes, some of which can be fatal. Current treatments can be limited and some patients may also go on to develop leukaemia.

The scientists found that up to 12% of patients with the different blood disorders had tiny mutations in one important gene, called 'EZH2'.

The particular region of DNA on which it was found, chromosome 7, was known to be prone to abnormalities in blood disorders, but this is the first time that a clear 'target gene' in this important region has been identified. The presence of mutations in the EZH2 gene also appeared to be a sign of poor prognosis for patients with these disorders.

The study, which was funded by the blood cancer charity Leukaemia & Lymphoma Research, is published online in the journal Nature Genetics on 4 July.

EZH2 is an important 'master regulator' gene that influences how blood cells are produced. The researchers, from Wessex Regional Genetics Laboratory in Salisbury and the University of Southampton, believe that any damage to its function is likely to have a major effect of blood cell development and lead to uncontrolled cell division.

Professor Nick Cross from the University of Southampton's School of Medicine, who led the research team, said: "The identification of this key genetic mutation and its connection with a significant percentage of cases provides a new and unexpected insight into the development of blood disorders. More work needs to be done but it is certainly possible that in the future this information could be used to guide treatments and design new drugs to correct genetic mutations."

Dr David Grant, Scientific Director at Leukaemia & Lymphoma Research, said: "This is an exciting piece of research. Unfortunately there are still limited treatment options available for blood disorders so identifying the genes that play a role in their development is an important step forward in our understanding."

Notes

1. The report is published online from 4 July 2010 in the journal Nature Genetics under the title 'Inactivating mutations of the histone methyltransferase gene EZH2 in myeloid disorders'. The corresponding author is Prof Nicholas Cross of the Human Genetics Division, University of Southampton and the Wessex Regional Genetics Laboratory, Salisbury. The study was funded by the blood cancer charity Leukaemia & Lymphoma Research.

2. The blood disorders MDS and MPN are diagnosed in over 5,000 people in the UK every year and although more common in the elderly they can affect people of at any age.

Source:
Leukaemia & Lymphoma Research
University of Southampton

Study Published In 'Nature Genetics' Identifies Key Gene Linked To Blood Disorders