Outbreak of Antiviral Drug–Resistant Influenza A in Long-Term Care Facility, Illinois, USA, 2008

DOI: 10.3201/eid1512.081644
Suggested citation for this article: Dharan NJ, Patton M, Siston AM, Morita J, Ramirez E, Wallis TR, et al. Outbreak of antiviral drug–resistant influenza A in long-term care facility, Illinois, USA, 2008. Emerg Infect Dis. 2009 Dec; [Epub ahead of print]

Outbreak of Antiviral Drug–Resistant Influenza A in Long-Term Care Facility, Illinois, USA, 2008

Nila J. Dharan,1 Monica Patton,1 Alicia M. Siston,2 Julie Morita, Enrique Ramirez, Teresa R. Wallis, Varough Deyde, Larisa V. Gubareva, Alexander I. Klimov, Joseph S. Bresee, and Alicia M. Fry

Author affiliations: Centers for Disease Control and Prevention, Atlanta, Georgia, USA (N.J. Dharan, M. Patton, T.W. Wallis, V. Deyde, L.V. Gubareva, A.I. Klimov, J.S. Bresee, A.M. Fry); and Chicago Department of Public Health, Chicago, Illinois, USA (A.M. Siston, J. Morita, E. Ramirez)
1Current affiliation: New York University School of Medicine, New York, New York, USA. 2Current affiliation: Centers for Disease Control and Prevention, Atlanta, Georgia, USA.

An outbreak of oseltamivir-resistant influenza A (H1N1) occurred in a long-term care facility. Eight (47%) of 17 and 1 (6%) of 16 residents in 2 wards had oseltamivir-resistant influenza A virus (H1N1) infections. Initial outbreak response included treatment and prophylaxis with oseltamivir. The outbreak abated, likely because of infection control measures.

Outbreaks of influenza virus infection cause illness and death, especially among residents of long-term care facilities (LTCFs). In addition to annual vaccination and infection control measures, antiviral agents for treatment and prophylaxis are useful components for control of influenza outbreaks in LTCFs (1–4), especially in years with vaccine strain mismatches (4).

Two classes of antiviral agents are licensed for use in the United States: adamantanes (amantadine and rimantadine) and neuraminidase inhibitors (oseltamivir and zanamivir). Circulation of influenza A viruses resistant to both classes of antiviral agents, A (H3N2) to...

abrir aquí para acceder al documento completo (9 páginas, PDF):
http://www.cdc.gov/eid/content/15/12/pdfs/08-1644.pdf